Christina Haston is an associate professor of medical physics at UBC’s Okanagan campus. - Credit: UBCO

UBC study could spare cancer patients from side effects of radiation

Her research has drawn a connection of Chromosome 6 genes to pulmonary fibrosis susceptibility.

A UBC Okanagan researcher has determined that genes on a specific chromosome may be the answer as to why thoracic radiotherapy leads to a lung injury in some lung cancer patients.

Christina Haston, an associate professor of medical physics, recently published a study examining how Chromosome 6 can contribute to radiation-induced pulmonary fibrosis. Her study finds that genetic differences can determine whether or not this lung injury follows radiotherapy in an experimental system, according to UBCO in a news release.

“Currently, 50 per cent of cancer patients in Canada receive radiation therapy as part of their treatment course,” she said. “In addition to effects on the tumour, up to 30 per cent of these patients develop side effects to this treatment, or injuries to non-tumour tissue.”

RELATED: UBC Okanagan study evaluates virtual educational care

Pulmonary fibrosis is a progressive disease related to damaged lung tissue, making it difficult for patients to breathe and process oxygen effectively. Some lung cancer patients have developed pulmonary fibrosis after radiation, while patients with other cancers have developed it after receiving a specific cancer medication called Bleomycin.

“One of the limiting side effects of thoracic radiotherapy is the development of pulmonary fibrosis in a susceptible subpopulation of treated patients,” said Haston. “However, the specific pathways contributing to fibrosis susceptibility in radiotherapy patients remain unidentified.”

It has been thought that white blood cells, the body’s natural defence mechanism, may contribute to pulmonary fibrosis. Building on this, her research has drawn a connection of Chromosome 6 genes to fibrosis susceptibility, the release said.

She examined the susceptibility to pulmonary fibrosis on lab mice after radiation therapy and on mice after treatment of Bleomycin. The mice with a replaced Chromosome 6 were protected from both radiation-induced and Bleomycin-induced pulmonary fibrosis.

RELATED: Globe trotting biology student to study at UBCO

“The recent findings by our lab have specifically identified these genetic differences to reside in Chromosome 6,” she added, explaining that her work may open the door to individualized cancer treatments, depending on a person’s specific genetic makeup.

Her study, published in Radiation Research, was supported by the Canadian Institutes of Health Research.

“This research aims to develop a pre-treatment marker based on knowledge of specific genes of radiation injury response,” she said. “Such a marker could significantly affect Canadians with cancer, by sparing side effects and increasing the dose to the tumour which may, in turn, increase cure rates.”


edit@kelownacapnews.com

Like us on Facebook and follow us on Twitter.

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

Carsen Gray set to launch first children’s book co-created with mom Lynn Hughan

Gray, Hughan launch ‘Twelve Months of Fun on Haida Gwaii with Mattie and Jojo’ on July 23

Federal government urged to protect rare moss clinging to life on Moresby Island cliff

Scientists say small patch of slender yoke-moss struggling to survive on square metre of limestone

Southern section of QC Main temporarily closing this month

QC Main (South) will be closed to all traffic at about 5 kilometres from July 21 to 28

From the archives of the Haida Gwaii Observer

50 YEARS AGO (1970): Nine of 12 entries in the Beach Buggy… Continue reading

BC Ferries reopens limited hot food service between Haida Gwaii, Prince Rupert

Release on July 8 says hot food will be served in packaging

VIDEO: Masset Dance Troupe presents beachfront ‘promenade performance’

Troupe performed ‘A Mid Summer Day’s Dream’ for family, friends on July 4 and 5

B.C. NDP changing WorkSafeBC regulations to respond to COVID-19

Employers say reclassifying coronavirus could be ‘ruinous’

Baby raccoon rescued from 10-foot deep drainage pipe on Vancouver Island

‘Its cries were loud, pitiful and heartbreaking,’ Saanich animal control officer says

Statistical flaws led to B.C. wolf cull which didn’t save endangered caribou as estimated

Study finds statistical flaws in an influential 2019 report supporting a wolf cull

Windows broken, racist graffiti left on Okanagan home

Family says nothing like this has happened since they moved to Summerland in 1980s

B.C. man who went by ‘Doctor Ray Gaglardi’ charged with sex assault of teenage boys

The man, 75, is accused of assaulting teenage boys he met through Coquitlam-area churches

B.C.’s potential deficit $12.5 billion as spending spikes, taxes drop

Finance Minister Carole James gives COVID-19 outlook

Canadians torn on scaling back COVID-19 benefits to save money: poll

Of those surveyed, 78 per cent said they were worried about the size of the deficit

‘Trauma equals addiction’: Why some seek solace in illicit drugs

Part 2: Many pushed into addiction by ‘toxic stress,’ says White Rock psychologist

Most Read